Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by Adamantane derivatives
نویسندگان
چکیده
منابع مشابه
Heterogeneous conductance levels of native AMPA receptors.
The single-channel properties of AMPA receptors can affect information processing in neurons by influencing the amplitude and kinetics of synaptic currents, yet little is known about the unitary properties of native AMPA receptors in situ. Using whole-cell and outside-out patch-clamp recordings from granule cells in acute cerebellar slices, we found that migrating granule cells begin to express...
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Ionotropic glutamate receptors, which underlie a majority of excitatory synaptic transmission in the CNS, associate with transmembrane proteins that modify their intracellular trafficking and channel gating. Significant advances have been made in our understanding of AMPA-type glutamate receptor (AMPAR) regulation by transmembrane AMPAR regulatory proteins. Less is known about the functional in...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1997
ISSN: 0022-3751
DOI: 10.1111/j.1469-7793.1997.655ba.x